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This is especially important in endurance sports, where prolonged exercise at high intensities challenges the bodys ability to rapidly sustain energy production without exhausting glycogen stores

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Histologically, the most important features are (a) massive plasma cell infiltrate in the granulation tissue, (b) diffuse infiltration of neutrophils that form local collections, (c) absence or paucity of lymphocytes, and (d) large mononuclear cells with Donovan bodies