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Purine metabolism, ABC transporters, Renin secretion, FoxO signaling pathway, AminoacyltRNA biosynthesis, and cGMPPKG signaling pathway were the major metabolism pathways disturbed in obese mice

Gastrointestinal Adverse Events Of the adverse effects reported during GLP-1 RA clinical trials, gastrointestinal symptoms were the most frequent, with nausea and diarrhea very common, and vomiting, constipation, abdominal pain, and dyspepsia considered to be relatively common [97]

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