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Tirzepatide (brand names Mounjaro and Zepbound) resulted in a decrease in 10.1 percent of body weight at six months and semaglutide (brand names Ozempic, Wegovy, and Rybelsus) resulted in a decrease of 5.8 percent of body weight at six months, according to a 2024 study in JAMA Internal Medicine

The journey to find the correct maintenance dose is usually progressive and takes several weeks