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Limited biased agonism (log (/K A )) was observed at the E354Q GIP receptor (Figure 2H) GIP(1-30)NH 2 appeared to be biased away from IP 1 (2-fold) and towards pCREB (7-fold) compared to cAMP accumulation, although these did not reach significance (Supplementary Table S2)

However, in some cases, it can lead to severe issues such as failure of essential body organs and even death