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Although other therapeutic agents, such as colivelin, have been shown to restore the glycocalyx and reduce the plasma concentration of syndecan-1 in sepsis (127), it is not clear whether these agents are directly integrated into the glycocalyx from the circulation or whether the glycocalyx is restored by de novo synthesis by endothelial cells

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Thus, phase I and II metabolism reduces curcumins bioavailability and alters the structural and chemical interactions of curcumin and its metabolites (119)

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Telomerase activity is high in healthy follicles, whereas NF-kB expression in granulosa cells is inversely associated to oocyte mass and telomerase activity, implying that post-inflammatory alterations in granulosa cells are deleterious to oocyte development (63)

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