Several phytochemicals, including berberine and other isoquinoline alkaloids, inhibit the assembly and activation of NLRP3, reducing mature pro-inflammatory cytokine release and mitigating neuroinflammation and neuronal loss in PD models ( Beyond immunomodulation, many plant phytoconstituents exert antioxidant and mitochondrial protective effects that are crucial in neurodegeneration
Lee PR, Cohen JE, Tendi EA, Farrer R, GH DEV, Becker KG, et al
doi:10.1016/j.ejphar.2005.12.015
Personally, I did have a bit of darkening of my facial hair but that was about it, and it returned to normal within a couple months of discontinuing the drug
NCT05934110
Midwest are the regions with the highest prevalence [3]