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SAM is additionally required for phosphatidylcholine synthesis, which is abundant in neuronal membranes and is crucial for synaptogenesis and neurite outgrowth ( Vitamin B12 is a cofactor for the enzyme methylmalonyl-CoA mutase, which converts methylmalonyl-CoA to succinyl-CoA, a crucial step in fatty acid metabolism (73)

Martinez-Correa, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Moreover, the role of mitochondria in fatty acid oxidation holds immense significance in liver metabolism