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JAMA J Am Med Assoc

These underlying biological changes can limit the progress you make with healthy habits, which can be disheartening and, despite your best efforts, increase your health risks

Side-by-Side Reference Attribute Class SLU-PP-332 Synthetic small-molecule pan-ERR agonist MOTS-c Mitochondrial-derived peptide (16 aa) AOD-9604 Modified GH fragment (aa 176-191) Attribute Primary target SLU-PP-332 ERR / / nuclear receptors MOTS-c AMPK activation and mitochondrial signaling AOD-9604 Lipolysis pathways without GH-receptor signaling Attribute Half-life SLU-PP-332 Not formally published

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Brain Sciences (2021) This study by an independent research group (outside the original Washington State University team) demonstrated that Dihexa rescues cognitive impairment in an Alzheimer's disease mouse model (APP/PS1 transgenic mice)