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Experimental studies have led to the identification of various cancer cell-intrinsic resistance mechanisms, e.g., activation and/or overexpression of drug transporter proteins (e.g., P-glycoprotein), altered expression of detoxifying enzymes (e.g., glutathione S-transferase) or resistance to apoptosis/senescence pathways [239-242]

Jonn Matsen and Dr

B., Dietary and genetic compromise in folate availability reduces acetylcholine, cognitive performance and increases aggression: critical role of S-adenosyl methionine

Hazan S, Dave S, Papoutsis AJ, Deshpande N, Howell MC, Jr., Martin LM

Results were striking

Tetrahydrobiopterin as a novel therapeutic intervention for autism