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Brittle cornea syndrome is characterized by thin corneaa, early-onset progressive keratoglobus (cornea becomes extremely thin and change to a more globular shape than its normal gradual curve.) or keratoconus (begins to bulge into a cone-like shape), and blue sclerae (the white of the eye) Classic symptoms, such as hypermobile joints and hyperelastic skin, are also seen often

"The role of dacarbazine and temozolomide therapy after treatment with immune checkpoint inhibitors in malignant melanoma patients: A case series and meta-analysis"

Published human data are limited and consist mainly of pilot studies and retrospective observations

10.4155/fmc-2022-0309 25 ChiefariE.ArcidiaconoB.FotiD.BrunettiA

When levels are managed correctly, side effects are minimal

le Roux CW, Bueter M, Theis N, Werling M, Ashrafian H, Lwenstein C, Athanasiou T, Bloom SR, Spector AC, Olbers T, Lutz TA