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Conversely, overexpression of GCH1 has been shown to selectively enhance BH4 biosynthesis, decrease ROS production and thereby inhibit ferroptosis (42)

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Functions and Classification of Ferroptosis Regulators Ferroptosis has several special cellular morphological characteristics that differ from other forms of programmed death, mainly manifested in the loss of plasma membrane integrity, cytoplasmic and organelle swelling, and chromatin agglomeration [43]

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