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Its safe for occasional use, but consult your doctor before taking it regularly

Homocysteine reduces ATP production and cellular glucose consumption by inhibiting cytochrome C oxidase leading to more cellular injury (Zhai et al

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Y.PanziliusE.KobayashiS.IngoldI.et al (2017)

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When to Contact Your Healthcare Provider About Cold Sensitivity If cold sensitivity persists beyond 810 weeks, becomes severe, or is accompanied by shaking, extreme fatigue, or confusion, contact your prescribing clinician immediately