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The Journal of the American Medical Association published an article in June 2024 proving the point

Especially from the age of 40, they are an unloved companion on our face, hands, arms or shoulders

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At lower doses, patients often experience fewer gastrointestinal symptoms such as nausea or vomiting, which can occur when GLP-1s are escalated too quickly

Loss of appetite may also result in reduced fluid intake, increasing the risk of dehydration and electrolyte imbalances

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