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These findings demonstrate that both basal and agonist-induced GLP-1R phosphorylation are critical for receptor signalling in -cells, revealing a previously unappreciated role for basal phosphorylation in shaping receptor behaviour and establishing a positive link between GLP-1R phosphorylation and -cell signalling competence

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Remarkably, CRP, YKL-40, and ICAM-1 were rapidly reduced within the first 4 th weeks of treatment, while leptin was gradually reduced till the time of trial

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Timeline: What to Expect Week by Week Setting realistic expectations helps maintain motivation and prevents disappointment from unrealistic timelines