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Without training stimulus, benefit is smaller

The growing prevalence and spectrum of NTHi antibiotic resistance necessitates changes to antibiotic treatment guidelines that carefully balance intended clinical outcomes with the risk of further promoting antibiotic resistance

In patients with severe [creatinine clearance (CrCl) less than 30 mL/min] or moderate (CrCl greater than or equal to 30 and less than 50 mL/min) renal impairment (CrCl calculated using the Cockcroft-Gault equation with actual body weight), the maximum recommended dosage is phentermine and topiramate extended-release capsules 7.5 mg/46 mg once daily

This action elevates circulating IGF-1 levels and enhances cellular repair, metabolism, and tissue regeneration without direct hormonal supplementation

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These are strategic decisions that either align with or work against the broader healthspan objectives of the combined approach