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A meta-analysis published in The Lancet Diabetes & Endocrinology (N=17 prospective studies) found that individuals in the highest quintile of circulating IGF-1 had a 25% increased relative risk of colorectal cancer compared to the lowest quintile [12]

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[PubMed] [Google Scholar] [101].Mosca M, Baldini C, Bombardieri S

Under carefully engineered pharmacologic conditions, it may become a complementary metabolic signal that helps transform incretin therapy from appetite suppression alone into a more comprehensive strategy targeting appetite, substrate oxidation, hepatic metabolism, and energy expenditure

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