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If you have a family history of medullary thyroid carcinoma or MEN2, understand that GLP-1 medications are not options for you
Nevertheless, as a precaution, its use is generally contraindicated in individuals with active cancers
Combining GLP-1R and GCGR agonists has emerged as a promising strategy to overcome these challenges
FDA reviewers found no human clinical trials at all supporting the proposed uses
As of 2025, Eli Lilly has not announced Phase 3 trials for oral tirzepatide, suggesting approval is at least 5-10 years away if the program proceeds successfully
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