General adverse events The most frequently reported adverse reactions across trials included gastrointestinal events such as nausea, diarrhea, vomiting, constipation, and abdominal pain
GLP-1 receptor agonists should be considered when patients experience significant weight regain with BMI 27 kg/m with obesity-related comorbidities or BMI 30 kg/m, lifestyle modifications have been insufficient, no anatomical complications require surgical revision, and patients are willing to engage in long-term pharmacotherapy
Its mild acidity helps break up aggregates in "sticky" peptides such as some GHK-Cu preparations
Many participants discussed the challenges associated with ensuring adequate protein and overall nutrient intake when appetite is suppressed by GLP-1 medications
Red flags include pressure to purchase without evaluation, no prescriber information, or claims of guaranteed weight loss or diabetes reversal
Gastroenterol Clin North Am 52(2):363380 Arterburn DE, Telem DA, Kushner RF, Courcoulas AP (2020) Benefits and risks of bariatric surgery in adults: a review