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Approximately five of the 19 peptides are expected to remain on the Category 2 list due to more significant safety concerns or weaker human evidence

The American Academy of Clinical Endocrinologists now recommends treating obesity with GLP-1 medications as a chronic condition requiring ongoing therapy, similar to how hypertension or type 2 diabetes are managed

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Another feature of GLP-1 was its action to inhibit glucagon secretion [35], whereas GIP stimulated glucagon secretion [36]