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It was found that six RNA modification-related genes (ADAMDEC1, IGHM, OGN, TNFRSF11B, SCARA3 and PTN) were identified as possible biomarkers of OA and RA pathogenesis [124]

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Recent studies indicate that ferroptosis indicators, including GPX4 and SLC7A11, are reduced in osteoarthritic chondrocytes, although lipid peroxidation and iron buildup are elevated [92,93]