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Inhibitors of GH Secretion Several factors can suppress GH release: Somatostatin (also from the hypothalamus) directly inhibits GH secretion Hyperglycemia (high blood sugar) Elevated IGF-1 levels (negative feedback) Chronic stress or high cortisol levels Poor sleep and circadian disruption GHRH Analogues: Peptides That Mimic Natural Signals Several peptides have been developed to mimic the action of GHRH, improving GH release in a physiologically balanced way

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The bidirectional interactions between thyroid function and the gut microbiota constitute the emerging concept of the gutthyroid axis, providing a novel framework for understanding the disease

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10.1016/j.neurol.2025.08.002 [DOI] [PubMed] [Google Scholar] 42.IIH-Advance In: University of Birmingham