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The body simply doesnt use it the same way

Ouabbou S, He Y, Butler K, Tsuang M

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Broadly, these findings suggest that cell-surface DAT levels are sensitive to membrane potential changes, which can rapidly drive DAT internalization from and insertion into the cell membrane, thus having an impact on the capacity for DAT to regulate extracellular dopamine levels. Khoshbuoei likenes the dopamine transporter to a powerful, efficient vacuum cleaner that maintains the brains chemical balance by rapidly absorbing dopamine back into the cells

For a broader explanation of GLP-1 treatment, you can read TrimRxs 2026 breakdown of what GLP-1 means