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One clinical trial has tested the safety and efficacy of CB4211, a MOTS-c analogue, in the treatment of obese subjects with nonalcoholic fatty liver disease, where it was found to be effective at reducing body weight and liver fat content

A substantial number of studies in people have evaluated evening primrose oil for atopic dermatitis or breast pain or for starting labor

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This effect is similar to what happens when you eat something that irritates your digestive system, like spoiled food or too much caffeine your body tries to flush out the contents rapidly

In the absence of population-specific data, clinical use should be accompanied by vigilant monitoring for class-wide effects (particularly gastrointestinal symptoms) and agent-specific concerns, with dose titration individualized to tolerability