This method of delivery allows for faster and more efficient absorption of the substances, as they bypass the digestive system and are immediately available to the body
Common side effects may include: Nasal irritation: Some people may experience nasal irritation, such as itching, burning, or stinging sensations in the nasal passages
PLoS One 19 , e0294847 (2024)
Cladribine, gemcitabine, lovastatin, and tamoxifen overall have lower IC 50 than the NO-based drugs, which are part of a few cancer and melanoma clinical trials (NCT00060710, NCT05502900) and pronouncedly reduced viability in both, metastatic and therapy-resistant melanoma cell lines (see Supplementary File 1)
doi:10.1159/000490284 Spiegel R, Kalla R, Mantokoudis G, et al
Delivery of antisense oligonucleotides for splice-correction of androgen receptor pre-mRNA in castration-resistant prostate cancer models using cell-penetrating peptides