It has been demonstrated that the loss of NPC1 impairs the proper function of the autophagy process (Sarkar et al., 2013)
On the other hand, in case of excessive distress, cells are exposed to high levels of ROS which can cause neuroinflammation, damage to the blood-brain barrier (BBB) and impairment to astrocyte crosstalk leading to ASD (El-Ansary et al., 2018
Conclusions : It appears that 500 M and pathophysiological concentrations (800 M) of UA induce antioxidant cell response in J744A.1 macrophages proved by the indicative elevation GCL, GPx1, GR, and GS transcription
gradally lightens dark
Different nodes represented distinct target proteins, and connections depicted their interaction relationships
Exp Gerontol 43:394408 Hacker H, Karin M (2006) Regulation and function of IKK and IKK-related kinases