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1 These include imipramine (Tofranil), midodrine (ProAmatine), chlorpheniramine (Chlor-Trimeton), brompheniramine (Veltane), ephedrine (Akovaz), pseudoephedrine (Sudafed), and phenylephrine (Vazculep)

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Concurrent dosing reduces efficacy by creating NAD+ demand spikes and competitive receptor saturationtiming separation is the critical variable for synergy

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Legrand M, Dupuis C, Simon C et al (2013) Association between systemic hemodynamics and septic acute kidney injury in critically ill patients: a retrospective observational study

Importantly, information regarding the indications, dosing, frequency, and duration of treatment remains unknown