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PMID: 22238404

Several studies have suggested the involvement of connexin and hemichannel signaling in APAP-induced acute liver failure

[DOI] [PMC free article] [PubMed] [Google Scholar] 24.Hiramatsu A, Aikata H, Uchikawa S, et al

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In most cases, side effects can be effectively managed by starting with a lower dose and gradually increasing it under the guidance of a healthcare provider