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Apolipoprotein E (ApoE), a protein interacting with cell surface receptors to facilitate the uptake of lipoproteins [72], is postulated to hinder the clearance of soluble A from the brain by competing with soluble A for LRP1dependent cellular uptake into astrocytes [73]

In this study, nearly a third of patients lost 25% or more of their starting weight on the higher dose of semaglutide, compared with only 15% who lost that amount on 2.4 mg and none on the placebo

Those with a BMI of 30 or over, or 27 with issues like hypertension, diabetes, or high cholesterol, could find value in semaglutide

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That can be helpful

Tell your surgeon and anesthesiologist well ahead of time