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However, in guidelines published in 2012, the British Columbia Medical Association (Canadian Ministry of Health) recommended a dose of 1000 g/day for pernicious anemia or food-bound cobalamin malabsorption [34]

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Blood pressure effects have been favorable, with dose-dependent reductions in systolic blood pressure of 3.5-5.6 mmHg in the ATTAIN-1 trial, likely related to weight loss, reduced sodium intake, and direct vascular GLP-1 receptor effects

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