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[6] Signs and symptoms [edit] The signs and symptoms of Graves' disease virtually all result from the direct and indirect effects of hyperthyroidism, with the main exceptions being Graves ophthalmopathy, goiter, and pretibial myxedema (which are caused by the autoimmune processes of the disease)

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4 Research progress of the serine synthesis pathway in pan-cancer The transcriptional expression differences of key enzymes in the de novo serine synthesis pathway (including PHGDH, PSAT1 and PSPH) across pan-cancer specimens were systematically analyzed using the Timer online database ( Figure 2 ), revealing the expression heterogeneity and potential tumor-specific expression patterns of these enzymes in distinct cancer types

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