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Homologous recombination (HR), an error-free DNA DSB repair mechanism, is deficient in many tumors, leading to enhanced sensitivity to widely clinically used DNA damaging agents

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This means they primarily act when blood sugar levels are rising, such as after a meal

The study indicated that the treatment of low dose selenite led to a just marginal increase in GPx activity in NIH3T3, MCF-7, and Sup-T1 cells, whereas identical treatment led to ~ fivefold increase of GPx activity in PC12 and AA8 cells

C-peptide response and HLA genotypes in subjects with recent-onset type 1 diabetes after immunotherapy with DiaPep277: an exploratory study