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Second, although standardized definitions for MACEs and composite renal outcomes were applied in this analysis, heterogeneity exists in the definitions of these endpoints across the included trials (e.g., variations in component events or eGFR decline thresholds), which should be considered when interpreting the pooled estimates

DOI: 10.1056/NEJMoa2032183 [^2]: Rubino D, Abrahamsson N, Davies M, et al

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Sandhu, and A

involvement of other systems possibly determining a functional impairment