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Memeo A., Loiero M

NMDA receptor signaling is mediated by Ca2 + permeability and the C-terminal domain of GluN2 subunit-associated network signaling and scaffold proteins

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Common clinical drivers include: Vitamin B12 deficiency Folate deficiency Chronic liver disease Alcohol use disorder Medications (e.g., methotrexate) Bone marrow disorders Chronic inflammatory disease Hypothyroidism Key ICD-10 principle: Cell size is a laboratory observation

This is a critical consideration for laboratory protocols

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