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The use of GLP-1R agonists was associated with fewer intra-articular injections of steroids and a lower cartilage loss velocity from the medial femoral joint, but the direct effects of GLP-1R agonist, apart from the weight loss-mediated pathway, did not reach statistical significance

available over-the-counter or on prescription (treatment should be reviewed after 12 weeks) Semaglutide (Wegovy) : GLP-1 receptor agonist for chronic weight management in eligible patients through specialist services Liraglutide (Saxenda) and naltrexone/bupropion (Mysimba) : Licensed options with variable NHS commissioning