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The main reason is receptor desensitization : continuous stimulation of the same receptor makes cells less responsive over time, so a planned off period lets the receptor resensitize

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Either option works, but taking it in the morning on an empty stomach allows it to enter your system faster and may help you burn more fat

BMC Cancer 8:122

These discussions require documentation, informed consent, and close monitoring protocols

if you are busy or forgetful, injections may be easier to keep up