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Combination of electroconvulsive stimulation with ketamine or escitalopram protects the brain against inflammation and oxidative stress induced by maternal deprivation and is critical for associated behaviors in male and female rats

This idea suggests that future studies should measure the balance between oxidative stress and antioxidant activity

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Verdict: Limited evidence DSIP has some small human sleep studies, but no large modern insomnia RCTs or meta-analyses were identified [47]