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GLP-1R agonist treatment induced insulin-like growth factor-2 secretion and promoted expression of its receptor, which has been suggested to enhance the pro-survival actions of GLP-1 in islet beta-cells

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By reducing body fat, GLP-1 medications may lower circulating estrogen levels, potentially reducing the fuel that drives endo growth

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GLP-1 RAs mimic naturally occurring GLP-1, an enterohormone produced in response to oral intake that regulates glucose metabolism and promotes weight loss