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[1] [3] Importantly, patients should seek urgent medical attention if they experience severe or persistent abdominal pain (especially if radiating to the back), repeated vomiting, inability to keep fluids down, signs of dehydration, or jaundice, as these may indicate serious conditions such as pancreatitis or gallbladder disease

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Additionally, the hepatic isoform alpha of the liver X receptor (LXR) is required for SREBP1c phosphorylation in a separate mechanism

Not just symptom presence, but symptom progression across defined intervals

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