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In Phase 2 trials, participants achieved an average weight loss of 24.2% of their body weight over 48 weeks

evidence from NSDUH 2019 and an online convenience sample

Beyond the scale There is a pivotal study called the SELECT Trial, published in 2023, that showed reduction in cardiovascular events in people with overweight or obesity and cardiovascular disease who took semaglutide, Abushamat said

You may regain weight once you stop taking the medication, unless you make some significant behavioral changes, like doing regular strength training