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Vitamin B12 deficiency mainly leads to haematological, neuropsychiatric, or cardiovascular manifestations

updated and replaced by NG246) NICE

The elevated levels of homocysteine may contribute to the development of depression by increasing oxidative stress, DNA damage, and cell death in the body

These functional defects are related to mTORC2-mediated dysregulation of cytoskeletal organization (including actin polymerization) and cell survival pathways