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High-dose oral therapy (10002000 micrograms daily) can be effective even in pernicious anaemia, as approximately 1% of B12 is absorbed through passive diffusion independent of intrinsic factor

Despite yielding the most reliable values and being less traumatic, micropuncture is limited by its depth of penetration which does not exceed 1 mm [11]

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This affects cell differentiation, apoptosis, mobility, and gene expression in stress contexts

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References [edit] "Inorganic Cyanide as Protecting Group in the Stereospecific Reconstitution of Vitamin B 12 from an Artificial Green Secocorrinoid" (PDF)