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Loss of VadK causes methylcitrate cycle hyperflux, disrupting central carbon metabolism, redox balance and bioenergetics
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Clinical and preclinical studies report effects on oxytocin, kisspeptin, and gonadotropins that may shift libido or ovulation windows
Further, the T1D high-risk HLA allele DR4, but not DR3, is more prevalent in patients with immunotherapy-induced diabetes compared with reported frequencies in patients who develop spontaneous T1D
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