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Wegovy comes as a once-weekly injection and is available in the UK at doses starting from 0.25mg, working up to 2.4mg

Different from the active dimer of IGF1R, the two membrane-proximal FnIII-3 domains in the structure of IR ectodomain bound to insulin tightly pack against each other 15

Metabolism (2003) 52:163842

Table 1 Literature identification strategy used in the narrative review

144, 507511 10.1016/S0021-9258(18)72535-0 [DOI] [Google Scholar] 7.Kimura H

Major cardiovascular outcome trials include: LEADER trial (liraglutide): Demonstrated a significant reduction in major adverse cardiovascular events (MACE) in patients with type 2 diabetes and high cardiovascular risk SUSTAIN-6 (semaglutide): Showed reduced cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke REWIND (dulaglutide): Confirmed cardiovascular benefits across a broad patient population SELECT trial (semaglutide): Showed reduced MACE in people with obesity without diabetes, though this evidence is not yet fully incorporated into UK labelling [17] These trials consistently found that the modest heart rate increases observed did not translate into adverse cardiovascular outcomes