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During sleep, cerebrospinal fluid (CSF) flows through brain tissue, helping remove metabolic waste products and proteins that accumulate throughout the day

Glutathione is also involved in metabolizing insulin and regulating blood glucose levels

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However, abnormal desensitization of insulin signaling has been observed in the brain tissue of patients with AD even in the absence of DM ( Multiple parallels between impaired brain insulin signaling in AD and insulin resistance in T2DM have been reported

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