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However, the effects vary from person to person, and in some cases, the delay in gastric emptying may lead to increased acid exposure, worsening ulcer symptoms

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The elevated IGF-1 levels as a result of insulin-resistance are thought to be responsible for vascular deterioration and modulation of its levels may help to mitigate these adverse effects [76]

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It is FDA-approved as Mounjaro (type 2 diabetes, 2022) and Zepbound (obesity, 2023)