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doi: 10.1056/NEJMoa2206038
Regarding pain modulation, various studies have reported that GLP-1 analogs exert antinociceptive effects on the central nervous system
It also enhances insulin sensitivity and regulates blood sugar levels, leading to improved metabolic health and weight control
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For example, a 2022 study found that people taking a weekly injection of tirzepatide (commonly sold under the brand name Zepbound) lost between 15% and 20% of their body weight over 72 weeks
Since both liraglutide and semaglutide are fatty acid acylated analogs of human GLP-1, their structures are identical
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