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INTRODUCTION The human body contains, on average, more microbial cells than human cells do, with approximately 38 trillion bacteria compared with 30 trillion human cells

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Moreover, NF-B pathway activation impaired the GSH/GPX4 axis by triggering HIF-2 generation (Zhang et al., 2024c)

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The mammalian lipoxygenase family includes six distinct isoforms (ALOXE3, ALOX5, ALOX12, ALOX12B, ALOX15, and ALOX15B), and the researchers found that only the absence of ALOX12 significantly reduced ferroptosis