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However, the clinical heterogeneity observed in PEM suggests that other pathophysiological systems, such as coagulation cascade abnormalities, autonomic dysfunction, and dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, may coexist within the same patient population and potentially interact with the mechanisms outlined in this framework

Disrupted BBB and the blood-cerebrospinal fluid barrier are evident in both sporadic and familial ALS, occurring before the onset of motor neuron degeneration (Fig

These compounds are strictly intended for research use only (RUO) and are not approved for human medical or therapeutic use

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10.1074/jbc.M114.618249 14

2, 24 May 2024, pp