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Failure of autophagy in this context promotes the accumulation of oxidative stress, aberrant signaling, mitochondrial damage, and chronic inflammation, collectively establishing a pro-tumorigenic cellular environment

Monitoring renal function is advisable, particularly in patients experiencing significant gastrointestinal symptoms that could lead to dehydration

Central abdominal obesity also leads to reduced lung volume, which decreases caudal tracheal traction and further increases risk of airway collapse [54]

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