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While GLP-1s dont replace CPAP or BiPAP therapy, they meaningfully reduce apnea severity by driving weight loss

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The first pathway requires a BMI greater than 27 combined with either prediabetes or established cardiovascular disease

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Subsequent trials demonstrated cardiovascular benefits: in the SUSTAIN 6 trial, semaglutide reduced major adverse cardiovascular events by 26% in high-risk patients, a finding that led to FDA approval for cardiovascular risk reduction in January 2020

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